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Neither type of compounded formulation undergoes FDA approval for safety and efficacy the way brand-name drugs do

Mutations in the retinoic acid receptor-related orphan receptors (ROR) also result in enhanced corticosterone secretion and ACTH response as well as a lack of diurnal variation compared to wild-type mice (33)

Surg Laparosc Endosc Percutan Tech 2019;29:221-32

Discontinue use if irritation occurs